• Skip navigation
  • Skip to navigation
  • Skip to the bottom
Simulate organization breadcrumb open Simulate organization breadcrumb close
GB.Com
  • FAUTo the central FAU website
  1. Friedrich-Alexander-Universität
  2. DFG-Graduiertenkollegs
Suche öffnen
  • Campo
  • StudOn
  • FAUdir
  • Jobs
  • Map
  • Help
  1. Friedrich-Alexander-Universität
  2. DFG-Graduiertenkollegs

GB.Com

Navigation Navigation close
  • GB.Com
  • About GB.Com
  • Team
    • Spokesperson & Scientific Director
    • Members
    Team
  • Projects
    • Gut-neural communication
      • Project A01
      • Project A02
      • Project A03
      • Project A04
    • Gut-brain communication
      • Project B01
      • Project B02
      • Project B03
      • Project B04
    • Central projects
      • Project Z01
      • Project Z02
    Projects
  • News
    • News on People
    News
  • Activities
    • Public Events
    • Scientific Lectures and Seminars
    • Recorded Lectures
    • Meetings
    • Press
    • Publications
    Activities
  • Scientific talent promotion
  • Contact
  • Intranet
  1. Home
  2. Projects
  3. Gut-brain communication
  4. Project B04

Project B04

In page navigation: Projects
  • Gut-neural communication
  • Gut-brain communication
    • Project B01
    • Project B02
    • Project B03
    • Project B04
  • Central projects

Project B04

Interplay between intestinal microbiome and multimodal MRI brain biosignatures for prediction of response to anti-TNF therapy in ulcerative colitis

Project Description

Ulcerative colitis (UC) is one of the major entities of inflammatory bowel diseases (IBD), causing lifelong morbidity. Apart from diarrhea and rectal bleeding, abdominal pain and ongoing fatigue may represent a great illness burden. Introduction of anti-TNF therapy has made a major impact on the clinical benefit of the patient. Nevertheless, it is only effective in a subgroup of patients and there is still a discrepancy between objective control of inflammation and subjective central perception of symptoms and patient related outcomes, respectively. Previous work from our group demonstrated that functional magnetic resonance imaging (fMRI) was able to visualize a rapid decreased pain perception in the brain of IBD patients responding to anti-TNF antibody therapy. With regard to the gut-brain axis it has been demonstrated, that the microbiome can substantially modulate local and systemic immunological processes, as well as brain function. Our project focuses on microbiome-brain interactions in UC patients under anti-TNF therapy using innovative multimodal MRI (mMRI) for defining functional and structural CNS biosignatures. This will lead to an improved, holistic understanding of the disease pathophysiology along the gutbrain axis and may consequently pave the way for an individualized patient stratification, clinical decision making and objective prediction of treatment response.

 

Project Leaders:

Raja Atreya

Prof. Dr. med. Raja Atreya

Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen

Arnd Dörfler

Prof. Dr. med. Arnd Dörfler

Leiter des Neuroradiologischen Instituts

MD student:

Kim Kaszuba

Kim Kaszuba

Associated Members:

Andreas Hess

Prof. Dr. rer. nat. Andreas Hess

Silke Kreitz

Dr. rer. nat. Silke Kreitz

Addition information

Categories

Search website

Friedrich-Alexander-Universität
Erlangen-Nürnberg

Schlossplatz 4
91054 Erlangen
  • Legal notice
  • Privacy
  • Accessibility
  • LinkedIn
Up