Immune checkpoints of but-brain communication in inflammatory and neurodegenerative diseases
| Project number | Project leaders | Project title |
|---|---|---|
| A01 | Prof. Dr. Beate Winner Department of Stem Cell Biology (SB) Prof. Dr. Markus F. Neurath Department of Medicine 1 | Deciphering immune interactions between iPSC-derived enteric neural lineages and 3D intestinal epithelial organoids in mucosal inflammation |
| A02 | PD Dr. Dr. Rocio López-Posadas Department of Medicine 1 Prof. Dr. Friederike Zunke Department of Neurology | Molecular mechanisms contributing to intestinal a-synuclein aggregation and pathology in PD |
| A03 | Prof. Dr. Christoph Becker Department of Medicine 1 Prof. Dr. Dieter Chichung Lie Department of Biochemistry | Role of neurogenesis and homeostasis in reciprocal gut-nervous system signaling |
| A04 | PD Dr. Dr. Stefan Wirtz Department of Medicine 1 Prof. Dr. Jürgen Winkler Department of Neurology | Role of dysbiotic microbiota for immune cell neuronal communication in the pathogenesis of Parkinson disease |
| Project number | Project leaders | Project title |
|---|---|---|
| B01 | Prof. Dr. Claudia Günther Department of Medicine 1 Prof. Dr. Veit Rothhammer Department of Neurology | Impact of microbiota-brain communication on MS-related autoimmunity |
| B02 | PD Dr. Dr. Iryna Prots Department of Stem Cell Biology (SB) Prof. Dr. Dr. Sebastian Zundler Department of Medicine 1 | Immune cell trafficking to the central nervous system as a critical factor for gut-brain communication |
| B03 | Prof. Dr. Kai Hildner Department of Medicine 1 Prof. Dr. Veit Rothhammer Department of Neurology | Impact of intestinal myeloid cells on the immune-neuronal crosstalk in the pathogenesis of synucleinopathies and colitis |
| B04 | Prof. Dr. Raja Atreya Department of Medicine 1 Prof. Dr. Arnd Dörfler Faculty of Medicine | Neuroradiological Institute Interplay between intestinal microbiome and multimodal MRI brain biosignatures for prediction of response to anti-TNF therapy in ulcerative colitis |
| Project number | Project leaders | Project title |
|---|---|---|
| Z01 | Prof. Dr. Beate Winner Department of Stem Cell Biology (SB) Prof. Dr. Claudia Günther Department of Medicine 1 Dr. Pooja Gupta Faculty of Medicine | Management and Administration of the Collaborative Research Unit |
| Z02 | Prof. Dr. Katharina Breininger Department Artificial Intelligence in Biomedical Engineering (AIBE) Prof. Dr. Stefan Uderhardt Department of Medicine 3 | Studying in situ tissue schematics using advanced volumetric imaging and machine learning for image analysis. |