Projects
Immune checkpoints of gut-brain communication in inflammatory and neurodegenerative diseases
Research area A: Mechanisms controlling gut-neural communication
| Project code | Project leader | Project title | Graphical Abstract |
| A01 |
Prof. Dr. Beate WinnerDepartment of Stem Cell Biology (SB)
Prof. Dr. med. Markus F. NeurathDepartment of Medicine 1
|
Deciphering immune interactions between iPSC-derived enteric neural lineages and 3D intestinal epithelial organoids in mucosal inflammation |  |
| A02 |
PD Dr. Dr. habil.med. Rocio López-PosadasDepartment of Medicine 1
Prof. Dr. rer.nat.Friederike ZunkeDepartment of Neurology |
Molecular mechanisms contributing to intestinal a-synuclein aggregation and pathology in PD |  |
| A03 |
Prof. Dr. rer.nat.Christoph BeckerDepartment of Medicine 1
Prof. Dr. Dieter Chichung LieDepartment of Biochemistry |
Role of neurogenesis and homeostasis in reciprocal gut-nervous system signaling |  |
| A04 |
PD Dr. rer. nat. Dr. med.habil. Stefan WirtzDepartment of Medicine 1
Prof. Dr. med. Jürgen WinklerDepartment of Neurology
|
Role of dysbiotic microbiota for immune cell neuronal communication in the pathogenesis of Parkinson disease |  |
Research area B: Impact of gut-brain communication on CNS
| Project code | Project leader | Project title | Graphical Abstract |
| B01 |
Prof. Dr. Claudia GüntherDepartment of Medicine 1
Prof. Dr. Veit RothhammerDepartment of Neurology
|
Impact of microbiota-brain communication on MS-related autoimmunity |  |
| B02 |
PD Dr. rer. nat. Dr. habil.med. Iryna ProtsDepartment of Human Genetics
Prof. Dr. med. Dr. rer. biol.hum. Sebastian ZundlerDepartment of Medicine 1
|
Immune cell trafficking to the central nervous system as a critical factor for gut-brain communication | 
|
| B03 |
Prof. Dr. med. Kai HildnerDepartment of Medicine 1
Prof. Dr. Veit RothhammerDepartment of Neurology
|
Impact of intestinal myeloid cells on the immune-neuronal crosstalk in the pathogenesis of synucleinopathies and colitis |  |
| B04 |
Prof. Dr. med. Raja AtreyaDepartment of Medicine 1
Prof. Dr. med. Arnd DörflerFaculty of Medicine
Neuroradiological Institute |
Interplay between intestinal microbiome and multimodal MRI brain biosignatures for prediction of response to anti-TNF therapy in ulcerative colitis |  |
Z-Project: CRU administration, central biomaterial, bioinformatics
| Project code | Project leader | Project title | Graphical Abstract |
| Z01 |
Prof. Dr. Beate WinnerDepartment of Stem Cell Biology (SB)
Prof. Dr. Claudia GüntherDepartment of Medicine 1
Dr. Pooja GuptaFaculty of Medicine |
Management and Administration of the Collaborative Research Center
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| Z02 |
Prof. Dr.-Ing. Katharina BreiningerDepartment Artificial Intelligence in Biomedical Engineering (AIBE)
Prof. Dr. med. Stefan UderhardtDepartment of Medicine 3
|
Studying in situ tissue schematics using advanced volumetric imaging and machine learning for image analysis. |  |